Journal of International Oncology ›› 2014, Vol. 41 ›› Issue (7): 515-517.doi: 10.3760/cma.j.issn.1673422X.2014.07.010

Previous Articles     Next Articles

The mechanism research of EGFRTKI resistance

 XIONG  Xing-An, WANG  Meng, CAI  Zhi-Qiang   

  1. Departmentof Pharmacy, First Affiliated Hospital of Yangtze University, Jingzhou,434000 China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: Cai Zhiqiang E-mail:helloasha@163.com

Abstract: Epidermal growth factor receptor  tyrosine kinase inhibitor (EGFRTKI) resistance in nonsmall cell lung cancer(NSCLC) has become more and more common, which includes primary and secondary resistance. The primary resistance is mainly related with EGFR gene mutation, and the secondary resistant is mainly related with T790M, MET and other genes.

Key words: Receptor,epidermal growth factor, Drug resistance,neoplasm, Tyrosine kinase inhibitor