Abstract: The occurrence of nasopharyngeal carcinoma is a multi-gene, multi-step process. Among them, oncogene activation and antioncogene inactivation is the important mechanism. The related oncogenes of nasopharyngeal carcinoma contain Bcl-2, HGF, COX-2 and LMP-1. The related antioncogenes of nasopharyngeal carcinoma contain P53, P16, NM23-H1 and PTEN. With the deepening research on genes, studies also find that nasopharyngeal carcinoma is related to PECAM-1, MMP-9 and RECK. These genes play important roles in the occurrence and development of nasopharyngeal carcinoma, which may become new targets for the treatment of nasopharyngeal carcinoma.

Key words: Nasopharyngeal neoplasms, Genes