Abstract: Myeloid-derived suppressor cells (MDSCs) play an important immunosuppressive role during the tumor development process. And the progression of many tumors are always accompanied with abnormal accumulation of MDSCs. Moreover, both the accumulation and functions of MDSCs could be affected by complicated factors. Therefore, how to effectively reduce the immunosuppressive effects of MDSCs in oncotherapy has become the focus of scholars. Recent studies show that anti-tumor drugs can affect many biological behaviors of MDSCs.

Key words: Myeloid cells, Antineoplastic agents, Immunosuppressive agents, Myeloied devrived suppressor cells