Abstract: Cytokines play an important role in the genesis and development of tumor. Antitumor mechanisms of some cytokines are clearly testified. Currently，the main cytokines used in tumor clinical treatments are interferons, interleukins and tumor necrosis factors. For the lack of specificity, there are too many side effects for some patients to continue. So the application range of cytokines in tumor clinical treatment is limited. The most important measures to develop cytokines therapy are improving the stability of curative effect and reducing side effects.

Key words: Interferons, Interleukins, Tumor necrosis factors, Cytokines therapy