Abstract:  Objective To investigate the expressions and significances of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus. Methods Immunohistochemistry was carried out to examine the expressions of SIRT1 and p53 in 39 cases of endometrial carcinoma with diabetes mellitus and 40 cases of endometrial carcinoma without diabetes mellitus and 25 cases of normal endometrium, and the correlations between these indexs were analysed. Results The positive rate of SIRT1 and p53 in experimental group was 64.1％, 59.0％ respectively, and 85.0％, 52.5％ in control group. The positive rate of SIRT1 in experimental group was lower than control group (χ²=4.561, P=0.033). The positive rates of SIRT1 and p53 in control group were higher than normal endometrium (χ²=21.462, P＜0.001; χ²=6.771, P=0.009). Expression of SIRT1 was positively correlated with p53 (r = 0.360，P =0.024). Conclusions Hyperglycemia deregulates SIRT1 in endometrial carcinoma. SIRT1 may promote tumorigenesis by silence of p53.

Key words: Endometrial neoplasms, Diabetes mellitus, type 2, SIRT1, Genes, p53