Abstract: Gap junctions are membrane structures made of intercellular channels that allow direct exchange of material and information between adjacent cells. It is the structural basis of gap junctional intercellular communication. A lot of data suggest that aberrant gap junction often involves in variety of cancer models, it relatives with tumorgenesis and metastasis. It may provide a novel therapeutic target for tumor treatment when utilize connexin to design new anti-cancer drug.

Key words: Connexins, Gap junctions, Neoplasms, Cell communication