Clinical significance of detection of mtMSI and Hp in the diagnosis of esophageal squamous cell carcinoma

doi:10.3760/cma.j.issn.1673-422X.2017.10.002

Abstract

Abstract: ObjectiveTo detect the mitochondrial microsatellite instability (mtMSI) and Helicobacter pylori (Hp) infection status in esophageal squamous cell carcinoma (ESCC), and to analyze their clinical significance in the diagnosis of ESCC. MethodsThe mtMSI and Hp infection status were examined by immunohistochemical SP method in 93 cases of ESCC and their normal control tissues. The relationship between Hp and mtMSI and their correlations with the clinicopathological features of ESCC were analyzed. ResultsThe Hp positive rates of ESCC group and control group were 61.3% (57/93) and 20.4% (19/93) respectively, and there was statistically significant difference between the two groups (χ2=32.127, P＜0.001). The mtMSI positive rates of ESCC group and control group were 34.4% (32/93) and 0 (0/93) respectively, and there was statistically significant difference between the two groups (χ2=38.649, P＜0.001). The Hp infection was correlated with tumor infiltrating degree (χ2=22.213, P＜0.001) and lymph node metastasis (χ2=8.318, P=0.004), but was not correlated with gender (χ2=0.330, P=0.565), major axis of tumor (χ2=0.692, P=0.406), gross type (χ2=1.006, P=0.316), differentiated degree (χ2=0.665, P=0.415). The mtMSI was not correlated with gender (χ2=0.163, P=0.686), major axis of tumor (χ2=0.384, P=0.530), gross type (χ2=0.422, P=0.516), differentiated degree (χ2=0.213, P=0.645), infiltrating degree (χ2=0.001, P=0.979) or lymph node metastasis (χ2=0.039, P=0.843). The Hp infection was positively associated with mtMSI in ESCC (r=0.864, P=0.006). ConclusionThe positive rates of Hp and mtMSI in ESCC are higher than those in normal tissues, and there is a close relationship between Hp and mtMSI. Hp is also associated with the progression of ESCC.

Key words: Esophageal neoplasms, Helicobacter pylori, Mitochondrial microsatellite instability

Peng Qianqian, Deng Sanhua, Chen Peisheng, He Fengjian, Xu Shenghao. Clinical significance of detection of mtMSI and Hp in the diagnosis of esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2017, 44(10): 727-730.

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