NOD2 gene and primary hepatocellular carcinoma

doi:10.3760/cma.j.issn.1673-422X.2013.12.015

Abstract

Abstract: Nucleotidebinding oligomerization domain protein 2 (NOD2) involves in host immune responses to pathogens and regulates natural immunity and specific immunity by identifying the peptidoglycan of bacterial cell walls and cleavage product muramyl dipeptide. As a newly discovered intracellular pattern recognition receptor, NOD2 plays important roles in the development of primary hepatocellular carcinoma by gene mutate, inducing liver inflammatory reaction and activating relevant signaling pathways.

Key words: Polymorphism, single nucleotide, Carcinoma, hepatocellular, Nucleotide-binding oligomerization domain protein 2

LIANG Ning, QIAO Li-Li, XIE Jian, ZHANG Jian-Dong. NOD2 gene and primary hepatocellular carcinoma[J]. Journal of International Oncology, 2013, 40(12): 927-929.

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