Journal of International Oncology ›› 2023, Vol. 50 ›› Issue (7): 437-441.doi: 10.3760/cma.j.cn371439-20230227-00084

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Research progress of 4-nitroquinoline-1-oxide-induced esophageal squamous cell carcinoma model in mice

Li Jinge1, Li Jing2, Zhang Zhenhan1, Guo Jianxin1, Wang Jingpu1, Wu Zhongbing3()   

  1. 1School of Integrated Chinese and Western Medicine,Hebei Medical University,Shijiazhuang 050017,China
    2Department of Traditional Chinese Medicine,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050019,China
    3Basic Research Office of Traditional Chinese Medicine,School of Integrated Chinese and Western Medicine,Hebei Medical University,Shijiazhuang 050017,China
  • Received:2023-02-27 Revised:2023-06-07 Online:2023-07-08 Published:2023-08-03
  • Contact: Wu Zhongbing,Email: wzb20181103@126.com
  • Supported by:
    National Natural Science Foundation of China(82274593);Hebei Medical University 2022 Undergraduate Innovative Experimental Program(USIP2022079)

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with a poor prognosis. 4-nitroquinoline-1-oxide (4NQO) is a water-soluble quinoline derivative that can successfully induce the production of squamous cell carcinoma in vivo. Establishing and optimizing experimental methods for 4NQO induced ESCC formation in mice can provide a more suitable in situ model for the study of ESCC.

Key words: 4-nitroquinoline-1-oxide, Esophageal squamous cell carcinoma