Advances of microRNA in the detection, treatment, drug resistance and prognosis of breast cancer

doi:10.3760/cma.j.cn371439-20200306-00115

Abstract

Abstract:

microRNAs (miRNAs) are abnormally expressed in patients with breast cancer, which can be used in diagnosis, treatment and monitoring of breast cancer. Different molecular types and clinical stages of breast cancer have significant differences in expression profiles of miRNAs. The combined detection of multiple miRNAs in nipple discharge, blood and tumor tissues can comprehensively evaluate the disease status, which are contribute to the early diagnosis and treatment of breast cancer. Monitoring the level changes of miRNAs after treatment are contribute to assessing the therapeutic effect, monitoring the prognosis of the disease and providing timely and effective treatment for disease recurrence and metastasis. Targeted regulation of miRNAs related to drug resistance is a new opportunity for the treatment of breast cancer.

Key words: microRNAs, Breast neoplasms, Early diagnosis, Biomarkers, pharmacological

Liu Hong, Wu Jian, Li Hongjiang, Yang Xiaoqin. Advances of microRNA in the detection, treatment, drug resistance and prognosis of breast cancer[J]. Journal of International Oncology, 2020, 47(12): 756-760.

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