国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (4): 271-273.doi: 10.3760/cma.j.issn.1673422X.2016.04.008

• 综述 • 上一篇    下一篇

SOX7及其在肿瘤中的表达和作用

何会萍,徐祖敏,官成浓   

  1. 524000湛江，广东医学院附属医院肿瘤科
  • 出版日期:2016-04-08 发布日期:2016-03-02
  • 通讯作者: 官成浓，Email: guanchengnong@163.com E-mail:guanchengnong@163.com

SOX7 and its expression and function in tumors

He Huiping, Xu Zumin, Guan Chengnong   

  1. Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China
  • Online:2016-04-08 Published:2016-03-02
  • Contact: Guan Chengnong E-mail:guanchengnong@163.com

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摘要： SOX7是转录因子SOX家族成员，调控多种生物学过程。研究发现SOX7基因是一个抑癌基因，其表达在绝大多肿瘤中下调，可能是通过调节Wntβ连环蛋白信号通路介导的转录过程抑制肿瘤的增殖、迁移和侵袭等生物学行为，在肿瘤的发生中起着重要作用。

关键词: 转录因子, 基因, 肿瘤抑制, SOX7

Abstract: SOX7 belongs to the SOX gene family. And it has been shown to regulate multiple biological processes. Studies have found that SOX7 gene is likely to be a tumor suppressor gene. In many tumors, SOX7 downregulation that inhibits proliferation, migration and invation of tumor via regulating the Wntβcatenin signaling pathway mediated the transcription process, which plays a significant role in tumorigenesis.

Key words: Transcription factors, Genes, tumor suppressor, SOX7