国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (4): 254-257.doi: 10.3760/cma.j.issn.1673422X.2016.04.004

• 论著 • 上一篇    下一篇

肺腺癌根治术后复发与转移的预后因素分析

张亚飞,刘攀,赵化荣,王珊珊,孙瑞瑞   

  1. 830011 乌鲁木齐，新疆医科大学第一附属医院肿瘤中心
  • 出版日期:2016-04-08 发布日期:2016-03-02
  • 通讯作者: 赵化荣，Email: xydyfyzhr@163.com E-mail:xydyfyzhr@163.com
  • 基金资助:

    乌鲁木齐市科学技术计划（Y141310033）

Prognostic factors of relapse and metastasis after radical resection of lung adenocarcinoma

Zhang Yafei, Liu Pan, Zhao Huarong, Wang Shanshan, Sun Ruirui   

  1. Cancer Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
  • Online:2016-04-08 Published:2016-03-02
  • Contact: Zhao Huarong E-mail:xydyfyzhr@163.com
  • Supported by:

    Urumqi Municipal Science and Technology Project (Y141310033)

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3187

被引次数

6

摘要： 目的探讨肺腺癌根治术后局部复发与远处转移的危险因素。方法收集2005年1月至2010年1月新疆医科大学第一附属医院收治的102例接受肺叶切除肺腺癌病例，对影响其预后的临床病理因素进行单因素及多因素分析，采用KaplanMeier绘制生存曲线，采用Logrank检验单因素统计学差异，采用COX回归比例风险模型对预后影响因素进行多因素分析。结果全组1、2、3、5年无瘤生存率分别为74.30%、58.00%、51.50%、44.90%，总的中位无瘤生存期为30个月。单因素分析结果显示，肿瘤直径（χ2=9.951，P=0.002）、临床类型（χ2=8.460，P=0.004）、肿瘤分化程度（χ2=4.807，P=0.028）、淋巴结转移情况（χ2=40.516，P=0.000）、病理分期（χ2=38.769，P=0.000）是影响肺腺癌患者根治术后局部复发和远处转移的预后因素。多因素分析结果显示，肿瘤直径（OR=1.943，95%CI为1.091～3.463，χ2=5.082，P=0.024）、肿瘤分化程度（OR=2.570，95%CI为1.451～4.552，χ2=10.467，P=0.001）、淋巴结转移情况（OR=3.196，95%CI为1.037～9.849，χ2=4.096，P=0.043）是影响患者术后局部复发和远处转移的独立预后因素。结论对于肺腺癌根治术的患者，肿瘤直径、肿瘤分化程度、淋巴结转移情况是独立的预后因素。

关键词: 肺肿瘤, 肿瘤复发, 局部, 肿瘤转移

Abstract: ObjectiveTo explore the risk factors of local relapse and distant metastasis after radical resection of lung adenocarcinoma. MethodsA total of 102 patients with lung adenocarcinoma operated in First Affiliated Hospital of Xinjiang Medical University from January 2005 to January 2010 were collected．The correlation between clinicopathological characteristics and prognosis was evaluated by singlefactor and multifactor analyses. The survival curves were plotted using KaplanMeier. Singlefactor analysis of statistical difference was tested using Logrank test. Multifactor analysis of prognostic factors were produced by COX regression proportional hazards model. ResultsIn the whole group, 1, 2, 3 and 5 year diseasefree survival rates were 74.30%, 58.00%, 51.50% and 44.90% respectively, and the median diseasefree survival was 30 months. Singlefactor analysis showed that tumor size (χ2=9.951, P=0.002), clinical type (χ2=8.460, P=0.004), differentiated degree (χ2=4.807, P=0.028), lymph node metastasis (χ2=40.516, P=0.000), pathological stage (χ2=38.769, P=0.000) were prognostic factors for local relapse and distant metastasis in postoperative patients with lung adenocarcinoma. Mutifactor analysis showed that tumor size (OR=1.943, 95%CI: 1.0913.463, χ2=5.082, P=0.024), differentiated degree (OR=2.570, 95%CI: 1.4514.552, χ2=10.467, P=0.001), lymph node metastasis (OR=3.196, 95%CI: 1.0379.849, χ2=4.096, P=0.043) were independent prognostic factors for local relapse and distant metastasis in postoperative patients with lung adenocarcinoma. ConclusionTumor size, differentiated degree and lymph node metastasis are independent prognostic factors for local relapse and distant metastasis in postoperative patients with lung adenocarcinoma.

Key words: Lung neoplasms, Neoplasm recurrence, local, Neoplasm metastasis