结外鼻型NK/T细胞淋巴瘤治疗现状

doi:10.3760/cma.j.issn.1673-422X.2015.07.022

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (7): 554-556.doi: 10.3760/cma.j.issn.1673-422X.2015.07.022

结外鼻型NK/T细胞淋巴瘤治疗现状

陶恒敏，魏玉梅，李宝生

250017 济南大学山东省医学科学院医学与生命科学学院；山东省肿瘤医院放疗六病区

出版日期:2015-07-08 发布日期:2015-05-26
通讯作者: 李宝生 E-mail:baoshli1963@163.com
基金资助:
山东省自然科学基金（ZR2014YL034）

Current status for the treatment of extranodal nasal type NK/T cell lymphoma

Tao Hengmin, Wei Yumei, Li Baosheng

School of Medicine and Life Sciences, University of Ji′nanShandong Academy of Medical Sciences; Sixth Department of Radiation Oncology, Shandong Cancer Hospital, Ji′nan 250117, China

Online:2015-07-08 Published:2015-05-26
Contact: Li Baosheng E-mail:baoshli1963@163.com

摘要/Abstract

摘要： 大部分结外鼻型自然杀伤(NK)/T细胞淋巴瘤(ENKTL)处于Ⅰ、Ⅱ期。由于较高的局部和系统性失败率，单纯放疗无法使早期患者获得高治愈率。同步或序贯放化疗成为早期ENKTL的标准治疗方案。对于Ⅲ、Ⅳ期患者，含左旋门冬酰胺酶（LASP）化疗方案的治疗效果最为显著。晚期及复发难治患者常规化疗缓解后，可以接受造血干细胞移植巩固治疗。

关键词: 淋巴瘤, 结外NKT细胞, 放射疗法, 药物疗法, 造血干细胞移植

Abstract: The most of extranodal nasal type NK/Tcell lymphoma (ENKTL) are in the Ⅰ/Ⅱ stage. Radiotherapy alone is insufficient to achieve a high cure rate for the early stage patients with ENKTL due to frequent local and systemic relapse. Concomitant/sequential chemotherapy and radiotherapy is the standard treatment for the early stage patients with ENKTL. For the patients with stage Ⅲ/Ⅳ ENKTL, regimens containing Lasparaginase are most effective. For the patients with advanced stage ENKTL or refractory recurrent ENKTL, hematopoietic stem cell transplantation may be considered when the remission is achieved.

Key words: Lymphoma, extranodal NKTcell, Radiotherapy, Drug therapy, Hematopoietic stem cell transplantation

陶恒敏，魏玉梅，李宝生. 结外鼻型NK/T细胞淋巴瘤治疗现状[J]. 国际肿瘤学杂志, 2015, 42(7): 554-556.

Tao Hengmin, Wei Yumei, Li Baosheng. Current status for the treatment of extranodal nasal type NK/T cell lymphoma[J]. Journal of International Oncology, 2015, 42(7): 554-556.

参考文献

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结外鼻型NK/T细胞淋巴瘤治疗现状

Current status for the treatment of extranodal nasal type NK/T cell lymphoma

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