Ikaros与儿童急性淋巴细胞白血病

doi:10.3760/cma.j.issn.1673-422X.2015.04.021

摘要/Abstract

摘要： Ikaros是造血细胞分化和免疫系统发育的重要调节因子，并且作为肿瘤抑制因子，Ikaros异常会阻滞T、B细胞的发育或导致肿瘤形成。在白血病患者中，Ikaros发生突变导致患者治疗反应下降及长期生存率降低。Ikaros在白血病发生和预后中的机制研究已成为人们关注的热点。

关键词: Ikaros转录因子, 白血病, 预后

Abstract: Ikaros is a regulatory factor playing an important role in control of the development of hematopoietic cells and immune system; and as a tumor suppressor, its aberration can cause both T and B lineage development arrest and neoplastic transformation, leading to insensitive to therapy and poor prognosis in actue lymphoblastic leukemia. Recently, researches on how Ikaros affects the leukemogenesis and prognosis become the focus of attention.

Key words: Transcription factor, Ikaros, Leukemia, Prognosis

易丽君；段君凯；李红. Ikaros与儿童急性淋巴细胞白血病[J]. 国际肿瘤学杂志, 2015, 42(4): 316-318.

YI Li-Jun-；Duan-Jun-Kai-；Li-Hong. Ikaros and childhood acute lymphoblastic leukemia[J]. Journal of International Oncology, 2015, 42(4): 316-318.

参考文献

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