假基因在肿瘤中的研究

doi:10.3760/cma.j.issn.1673-422X.2014.01.004

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (1): 11-13.doi: 10.3760/cma.j.issn.1673-422X.2014.01.004

假基因在肿瘤中的研究

曹林平, 吴健, 郑树森

310003杭州，浙江大学医学院附属第一医院肝胆外科，卫生部多器官联合移植研究重点实验室

出版日期:2014-01-08 发布日期:2014-01-22
通讯作者: 郑树森，E-mail:shusenzheng@zju.edu.cn E-mail:shusenzheng@zju.edu.cn
基金资助:
国家自然科学基金（81272281）；浙江省自然科学基金杰出青年项目(R2110125)

Research progress of pseudogenes in tumor

CAO Lin-Ping, WU Jian, ZHENG Shu-Sen

Dapartment of Hepatobiliary Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University; Key Laboratory of Combined Multiorgan Transplantation, Ministry of Public Health, Hangzhou 310003, China

Online:2014-01-08 Published:2014-01-22
Contact: ZHENG Shu-Sen E-mail:shusenzheng@zju.edu.cn

摘要/Abstract

摘要： 假基因是指基因组中与正常编码蛋白基因序列相似，但缺乏明确生理功能的基因序列。近年来研究表明，许多假基因在肿瘤中能够活跃转录并翻译蛋白，在遗传水平、转录水平和转录后水平调控基因的表达活性，然而其功能及作用机制还有待进一步探索。

关键词: 拟基因, 肿瘤, 微RNAs, RNA, 小分子干扰

Abstract: Pseudogenes are sequences in the genome that are similar to the gene sequences which can encode proteins normally, but are lack of a clear physiological function. Recently, researches show that pseudogenes can transcribe and translate actively, and can regulate the expression of genes at the genetical, transcriptional and posttranscriptional levels. However, their effects and mechanisms remain to be clarified.

Key words: Pseudogenes, Neoplasms, MicroRNAs, RNA, small interfering

曹林平, 吴健, 郑树森. 假基因在肿瘤中的研究[J]. 国际肿瘤学杂志, 2014, 41(1): 11-13.

CAO Lin-Ping, WU Jian, ZHENG Shu-Sen. Research progress of pseudogenes in tumor[J]. Journal of International Oncology, 2014, 41(1): 11-13.

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假基因在肿瘤中的研究

Research progress of pseudogenes in tumor

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