受体酪氨酸激酶抑制剂在恶性胶质瘤中的临床试验进展

doi:10.3760/cma.j.issn.1673-422X.2013.11.010

摘要/Abstract

摘要： 恶性胶质瘤的发生发展与受体酪氨酸激酶（RTK）过表达及其信号转导通路的异常激活密切相关，据此开发出的靶向治疗药物如RTK抑制剂、RTK下游信号通路抑制剂和多靶点抑制剂等能在分子水平上对恶性胶质瘤进行靶向性治疗，其中部分已通过临床试验，并取得良好疗效。

关键词: 神经胶质瘤, 临床试验, 受体蛋白质酪氨酸激酶抑制剂

Abstract: The occurrence and development of malignant glioma are closely related to abnormal overexpression and activation of receptor tyrosine kinase (RTK) signal transduction pathways. Targeted therapeutic drugs such as RTK inhibitors, RTK downstream signaling pathway inhibitors and multitarget inhibitors can targeting treat malignant glioma at molecular level, some of which have been investigated in clinical trials and achieved good therapeutic effects.

Key words: Glioma, Clinical trial, Receptor protein-tyrosine kinase inhabitor

朱浩, 徐锦芳, 沈宏. 受体酪氨酸激酶抑制剂在恶性胶质瘤中的临床试验进展[J]. 国际肿瘤学杂志, 2013, 40(11): 833-836.

ZHU Hao, XU Jin-Fang, SHEN Hong. Clinical trials of receptor protein tyrosine kinase inhabitors in malignant glioma[J]. Journal of International Oncology, 2013, 40(11): 833-836.

参考文献

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