头颈鳞状细胞癌的神经生物学

doi:10.3760/cma.j.issn.1673-422X.2013.11.009

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (11): 830-833.doi: 10.3760/cma.j.issn.1673-422X.2013.11.009

头颈鳞状细胞癌的神经生物学

杨嵘, 陆伟, 季彤

上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科

出版日期:2013-11-08 发布日期:2013-10-15
通讯作者: 季彤, E-mail：jitong70@hotmail.com E-mail:jitong70@hotmail.com
基金资助:
上海交通大学“医工(理)交叉研究基金”项目（YG2012MS58）

Neurobiology of head neck squamous cell carcinoma

YANG Rong, LU Wei, JI Tong

Department of OralMaxillofacial HeadNeck Oncology, Ninth People′s Hospital Affiliated to Shanghai Jiaotong University School of Medicine; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China

Online:2013-11-08 Published:2013-10-15
Contact: JI Tong, E-mail：jitong70@hotmail.com E-mail:jitong70@hotmail.com

摘要/Abstract

摘要： 肿瘤中存在新生神经，肿瘤细胞可通过神经新生进行神经周浸润。最新研究发现，癌细胞通过分泌细胞因子促进了神经细胞的分化与生长，而神经的分化和生长又反过来刺激肿瘤发展和转移。肿瘤神经新生与血管新生、淋巴新生类似，是肿瘤细胞与周围微环境相互作用的方式之一，对肿瘤细胞的生物学行为及预后具有重要影响。

关键词: 癌, 鳞状细胞, 肿瘤转移, 神经营养因子, 神经新生

Abstract: Neonatal nerves exist in tumor tissues, and tumor cells can invade nerve by neurogenesis. Current research shows that cancer cells can secrete cytokines to promote the differentiation and growth of nerve cells, in turn, the differentiation and growth of nerve cells can stimulate tumor development and metastasis. Neurogenesis is one way of interaction bettween tumor cells and microenvironment similar to angiogenesis and lymphangiogenesis, which has a major impact on biological behavior of tumor cells and prognosis.

Key words: Carcinoma, squamous cell, Neoplasm metastasis, Neurotrophic factors, Neurogenesis

杨嵘, 陆伟, 季彤. 头颈鳞状细胞癌的神经生物学[J]. 国际肿瘤学杂志, 2013, 40(11): 830-833.

YANG Rong, LU Wei, JI Tong. Neurobiology of head neck squamous cell carcinoma[J]. Journal of International Oncology, 2013, 40(11): 830-833.

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头颈鳞状细胞癌的神经生物学

Neurobiology of head neck squamous cell carcinoma

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