国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (12): 905-907.doi: 10.3760/cma.j.issn.1673-422X.2013.12.008

• 综述 • 上一篇    下一篇

ZHX2与肿瘤的相关性研究

付世杰, 郭庆河   

  1. 250102 济南护理职业学院解剖及组织胚胎学教研室
  • 出版日期:2013-12-10 发布日期:2013-12-26
  • 通讯作者: 付世杰 E-mail:jnwx-fushijie@163.com

ZHX2 and cancer

FU  Shi-Jie, GUO  Qing-He   

  1. Department of Anatomy and Histology and Embryology, Ji′nan Nursing Vocational College, Ji′nan 250102, China
  • Online:2013-12-10 Published:2013-12-26
  • Contact: FU Shi-Jie E-mail:jnwx-fushijie@163.com

摘要: 转录抑制因子ZHX2是ZHX蛋白家族的成员之一,在人体组织中广泛存在,通过转录抑制作用参与多种疾病的发生与发展。研究表明ZHX2与肝癌、多发性骨髓瘤、胃癌、结直肠癌等的发生发展密切相关,具有肿瘤治疗的潜在价值。

关键词: 锌指, 同源盒结构域蛋白质类, 肿瘤, 转录因子

Abstract: Transcription repressor ZHX2 is one of the members in ZHX protein family, which exists widely in human tissue and participates in the occurrence and development of various diseases. Researches show that ZHX2 is closely related to the occurrence and development of cancers, such as liver cancer, multiple myeloma, gastric cancer and colorectal cancer, which has the potential value of tumor treatment.

Key words: Zinc fingers, Homeodomain proteins, Neoplasms, Transcription factors