山奈酚的抗肿瘤作用

doi:10.3760/cma.j.issn.1673-422X.2013.12.004

摘要/Abstract

摘要： 【摘要】山奈酚是一种广泛存在于水果、蔬菜、中草药等天然植物中的黄酮类化合物，具有抗肿瘤、抗氧化、抗炎、抗焦虑、镇痛和抗过敏等广泛的药理作用。研究发现，山奈酚可降低罹患癌症的风险，可通过诱导细胞凋亡、调节细胞周期、抑制新生血管生成和肿瘤转移等作用抑制肿瘤细胞增殖和侵袭，并可通过调节氧化应激反应和抑制炎性因子发挥抗肿瘤作用，在肿瘤防治中具有广阔的应用前景。

关键词: 山奈酚类, 肿瘤, 细胞凋亡, 细胞周期

Abstract: Kaempferol is a kind of flavonoid compound that exists in natural plants including fruits, vegetables and Chinese herbal medicine. Kaempferol has extensive pharmacological activities, including antitumor, antioxidant, antiinflammatory, anxiolytic, analgesic and antiallergic activities. Researches show that Kaempferol can reduce the risk of cancer, can inhibit proliferation and invasion of tumor cells by inducing apoptosis, regulating cell cycle, inhibiting angiogenesis and tumor metastasis. Meanwhile, kaempferol can suppress tumor growth by regulating the oxidative stress reaction and inhibiting inflammatory cytokines. In a word, kaempferol has broad prospects in cancer prevention and treatment.

Key words: Kaempferols, Neoplasms, Apoptosis, Cell cycle

付成瑞, 李宝生. 山奈酚的抗肿瘤作用[J]. 国际肿瘤学杂志, 2013, 40(12): 892-895.

FU Cheng-Rui, LI Bao-Sheng. Antitumor mechanism of kaempferol[J]. Journal of International Oncology, 2013, 40(12): 892-895.

参考文献

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