国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 678-680.

• 综述 • 上一篇    下一篇

Notch信号转导通路与乳腺癌靶向治疗

张永渠, 豆晓伟, 张国君   

  1. 515041汕头大学医学院附属肿瘤医院乳腺中心

  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 张国君，E-mail: guoj_zhang@yahoo.com E-mail:guoj_zhang@yahoo.com
  • 基金资助:

    国家重点基础研究发展计划（2011CB707700）；国家自然科学基金（31271068）；教育部高等学校博士学科点专项科研基金（20124402110003）

Molecular targeted therapy for breast cancer patients based on Notch signal transduction pathway

ZHANG  Yong-Qu, DOU  Xiao-Wei, ZHANG  Guo-Jun   

  1. Department of Breast Center, Affiliated Cancer Hospital of Shantou University Medical College, Shantou 515041, China

  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: ZHANG Guo-jun, E-mail: guoj_zhang@yahoo.com E-mail:guoj_zhang@yahoo.com

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被引次数

1

摘要： Notch信号转导通路参与调控细胞增生、分化及凋亡。异常的Notch信号转导通路可以诱导转基因鼠乳腺癌的发生，而在乳腺癌患者中，高表达Notch受体和（或）配体则与预后不良相关，因此靶向抑制Notch信号转导通路可能对乳腺癌治疗有益。

关键词: 乳腺肿瘤, Notch信号转导通路, 分子靶向治疗

Abstract: Studied show that the Notch signal transduction pathway involves in the regulation and control of cell proliferation, differentiation and apoptosis. Aberrant Notch signaling can induce breast cancer in transgenic mice. High expressions of either Notch receptors or their ligands have been linked to poor prognosis in patients with breast cancer. Inhibition of Notch signal transduction pathway may be beneficial for breast cancer treatment.

Key words: Breast neoplasms, Notch siginal transduction pathway, Molecular targeted therapy