国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 674-677.

• 综述 • 上一篇    下一篇

乳腺癌干细胞分选及其异质性

孔冕, 林雨, 王军业等   

  1. 510080中山大学华南肿瘤学国家重点实验室(孔冕、王军业),高血压研究所(林雨);山东省泰安市中心医院乳腺外科(李宝江)
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 李宝江,E-mail: libaojiang28@sina.com E-mail:libaojiang28@sina.com
  • 基金资助:

    广东省科技计划(2010B031600066)

Separation of breast cancer stem cell and its heterogeneity

KONG  Mian, LIN  Yu, WANG  Jun-Ye, et al   

  1. State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou 510060, China
  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: LI Bao-jiang, E-mail: libaojiang28@sina.com E-mail:libaojiang28@sina.com

摘要: 乳腺癌干细胞的成功分选是进行乳腺癌干细胞研究的基础,目前人们可以通过多种方法使乳腺癌干细胞得到一定程度的富集。然而,在越来越多乳腺癌干细胞表面标志物被发现的同时,其异质性也成为人们关注的热点。如何最大程度地富集乳腺癌干细胞及解释其异质性,将为乳腺癌的干细胞治疗提供新思路。

关键词: 乳腺肿瘤, 干细胞, 生物学标记, 遗传异质性

Abstract: The successful separation of breast cancer stem cell (BCSC) is the foundation of BCSC research. At present, people could gather BCSC to some extent in a number of ways. However, as more and more biomarkers are found in BCSC separation, the heterogeneity becomes a hot spot. How to gather BCSC as much as possible and how to explain the heterogeneity could provide new insights in the treatment of breast cancer.

Key words: Breast neoplasms, Stem cells, Biological markers, Genetic heterogeneity