国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 671-674.

• 综述 • 上一篇    下一篇

甲状腺乳头状癌危险度相关基因研究进展

蒋烈浩, 葛明华, 凌志强   

  1. 325035温州医学院第一临床医学院(蒋烈浩、葛明华);浙江省肿瘤医院 浙江省肿瘤研究所(蒋烈浩、凌志强),头颈肿瘤外科(葛明华)
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 葛明华,E-mail: gemingh@163.com E-mail:gemingh@163.com
  • 基金资助:

    浙江省医药卫生科学研究基金计划(2010KYA037);浙江省卫生高层次创新人才培养工程基金[浙卫发(2008)134号];卫生部科学研究基金-浙江省医药卫生重大科技计划(WKJ2012-2-021)

Progression of risk related genes in thyroid papillary carcinoma

JIANG  Lie-Hao, GE  Ming-Hua, LING  Zhi-Qiang   

  1. First Clinical Medical College, Wenzhou Medical College, Wenzhou 325035, China; Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: GE Ming-hua, E-mail: gemingh@163.com E-mail:gemingh@163.com

摘要: 近年来研究发现BRAF、Runx2、Runx3、S100A4等基因在甲状腺乳头状癌中存在异常表达。这些基因的异常表达与甲状腺乳头状癌的侵袭性、淋巴结及远处转移、多灶性之间存在密切联系,并且可能对甲状腺乳头状癌的临床诊断及治疗具有重要价值。

关键词: 癌, 乳头状, 甲状腺肿瘤, 基因, 淋巴转移

Abstract: In recent years, the abnormal expressions of BRAF, Runx2, Runx3 and S100A4 genes in thyroid papillary carcinoma have been found in many studies. The abnomal expressions of those genes are closely related to the tumor invasion, lymph node metastasis, mulifocality of thyroid papillary carcinoma, which may be valuable in clinical diagnosis and treatment.

Key words: Carcinoma, papillary, Thyroid neoplasms, Genes, Lymphatic metastasis