国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 373-376.

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糖原合成酶激酶3β与白血病

王妍, 徐酉华   

  1. 400014重庆医科大学附属儿童医院儿童发育疾病研究省部共建教育部重点实验室，儿科学重庆市重点实验室，重庆市儿童发育重大疾病诊治与预防国际科技合作基地
  • 出版日期:2013-05-08 发布日期:2013-05-15

Glycogen synthase kinase 3β and leukemia

WANG  Yan, XU  You-Hua   

  1. Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Hospital of Chongqing Medical University, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China
  • Online:2013-05-08 Published:2013-05-15

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摘要： 糖原合成酶激酶3β（GSK3β）是一种保守的胞质丝氨酸/苏氨酸蛋白激酶，既可以负调控与白血病相关的经典Wnt、Akt等信号通路,也可以正调控转录核因子（NF-κB）、非经典Wnt、溶酶体凋亡等信号通路，从而调节白血病细胞的增殖、分化和凋亡。目前，多种GSK3β抑制剂以及激活剂在白血病研究中均有报道，它们在减少化疗不良反应、逆转耐药、增强对白血病细胞的杀伤等方面发挥重要作用。GSK3β有望成为白血病分子靶向治疗的靶点。

关键词: 糖原合成酶激酶3, 白血病, 信号传导, 分子靶向治疗

Abstract: Glycogen synthase kinase 3β (GSK3β) is a conserved cytoplasmic serine/threonine protein kinase. It can not only negatively regulate the classical Wnt and Akt signal pathways which are associated with leukemia, but also positively regulate the NF-κB, non-classical Wnt and lysosomal apoptosis signal pathways, thereby regulating the proliferation, differentiation and apoptosis of leukemia cells. At present, a variety of GSK3β inhibitors and activators have been reported in the researches of leukemia, which play important roles in reducing theadverse reactionsof chemotherapy, reversing multidrug resistance and enhancing killing effect to leukemia cells. GSK3β is expected to become a target of leukemia molecular targeted therapy.

Key words: Glycogen synthase kinase 3, Leukemia, Signal transduction, Molecular targeted therapy