国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (1): 5-8.

• 综述 • 上一篇    下一篇

Maspin基因在肿瘤中的研究进展

马国旗, 江浩   

  1. 233000 蚌埠医学院第一附属医院放疗科
  • 出版日期:2013-01-08 发布日期:2013-01-15

Maspin gene in tumor

MA  Guo-Qi, JIANG  Hao   

  1. Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China
  • Online:2013-01-08 Published:2013-01-15

摘要: Maspin是一种肿瘤抑制基因,属于丝氨酸蛋白酶抑制剂超家族成员,近年研究发现其通过抑制肿瘤血管生成,增加细胞黏附性,促进肿瘤细胞的凋亡,抑制肿瘤的发生和发展,并具有肿瘤转移抑制作用,有可能为基因治疗提供一条新途径。

关键词: 基因, Maspin, 肿瘤

Abstract: Maspin, one kind of tumor suppressor gene, belongs to the serine proteinase inhibitor (serpin) ultra family's member. Recent studies found that it suppresses the tumor occurrence and development and has the inhibition of tumor metastasis through suppressing the tumor angiogenesis and increasing the cell adhesion, which may be a new way for gene therapy.

Key words: Genes, maspin, Neoplasms