国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (12): 883-886.

• 综述 •    下一篇

肿瘤超甲基化基因1与肿瘤

郭淑芹, 马静静, 张云良   

  1. 071000 河北省保定市第一中心医院内分泌科
  • 出版日期:2012-12-08 发布日期:2012-11-15
  • 通讯作者: 张云良,E-mail：zyl1228@yahoo.com.cn E-mail:zyl1228@yahoo.com.cn

Hypermethylated in cancer 1 and neoplasms

GUO  Shu-Qin, MA  Jing-Jing, ZHANG  Yun-Liang   

  1. Department of Endocrinology, Baoding No.1 Central Hospital， Baoding 071000, China
  • Online:2012-12-08 Published:2012-11-15
  • Contact: Corresponding author: ZHANG Yun-liang，E-mail：zyl1228@yahoo.com.cn E-mail:zyl1228@yahoo.com.cn

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摘要： 肿瘤超甲基化基因1（HIC1）是一种转录阻遏因子，广泛存在于各种正常组织，定位于染色体17p13.3，这个区域在多种肿瘤中显示杂合子丢失或DNA超甲基化。HIC1作为一种新的肿瘤生物标志物，已经被证实在多种不同类型的实体肿瘤组织中因为异常甲基化而表达下调，且可能与肿瘤预后相关。HIC1作为抑癌基因，通过多种途径参与肿瘤的发生发展过程，与细胞增殖、肿瘤生长、血管发生等相关。因此肿瘤细胞内HIC1的异常甲基化、表达缺失或功能异常是肿瘤发生发展的重要机制之一，并可能成为治疗肿瘤新的潜在靶点。

关键词: 肿瘤, DNA甲基化, HIC1基因

Abstract: HIC1 (hypermethylated in cancer 1) encodes a transcriptional repressor, and extensively resides in various kinds of normal tissue.  HIC1 gene is located in chromosome 17p13.3，in which loss of heterozygote or super-methylation is frequently found in a variety of human cancers. As a new tumor marker, HIC1 has been confirmed down-regulated in a wide variety of solid cancers because of HIC1 promoter hypermethylation, and may be associated  with tumor prognosis. As a tumor suppressor, HIC1participates in the development of tumor process through various ways, and is involved in cell proliferation, tumour growth ,and angiogenesis. Therefore，the abnormal hypermethylation or the loss of expression of HIC1 in tumor cells or abnormal function could be one of the important mechanisms of tumor development，and may become a new potential therapeutic targets for cancer.

Key words: Neoplasms, DNA methylation, HIC1 gene