关键词: 胃泌素类, 微RNAs, 结直肠肿瘤

Abstract: It has been reported that the high expression of gastrins and their receptors promotes some colorectal neoplasms cells proliferation and inhibit apoptosis. MicroRNAs(miRNAs) are closely related to gene expression regulation in colorectal neoplasms. Researches show that miRNAs have multiple intersections in the regulatory network of colorectal neoplasms with the signal transduction pathway of gatrins which controls the proliferation of colorectal neoplasms. Gastrins perhaps control the proliferation of colorectal neoplasms cells through miRNA signal transduction pathways. These findings have greatly expanded the understanding of the pathogenesis of colorectal neoplasms and will provide new ideas and methods for the diagnosis and treatment of colorectal neoplasms.

Key words: Gastrins, MicroRNAs, Colorectal neoplasms