国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (5): 337-340.

• 综述 • 上一篇    下一篇

细胞周期蛋白E的调控与恶性肿瘤

郭翠萍；张国君   

  1.  汕头大学医学院附属肿瘤医院乳腺中心　汕头大学医学院肿瘤研究中心
  • 出版日期:2012-05-08 发布日期:2012-05-02
  • 通讯作者: 张国君,E-mail:guoj_zhang@yahoo.com E-mail:guoj_zhang@yahoo.com
  • 基金资助:

    国家自然科学基金资助项目（30973377）；广东省高等学校人才引进项目（粤教师［2008］86号）

Regulation of cyclin E and cancers

GUO Cui-ping, ZHANG Guo-jun   

  1. Breast Cancer, Affiliated Cancer Hospital of Shantou University Medical College, Cancer Reasearch Center of Shantou University Medical College, Shantou 515041, China
  • Online:2012-05-08 Published:2012-05-02
  • Contact: ZHANG Guo-jun, E-mail: guoj_zhang@yahoo.com E-mail:guoj_zhang@yahoo.com

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摘要： Cyclin E is expressed starting from the middle G1 phase of the cell cycle, and is accumulated in the G1/S boundry. Cyclin E binds to and activates the cyclindependent kinase CDK2. Cyclin E-CDK2 complex initiates a cascade of events that leads to DNA replication by phosphorylating its substrates, such as Rb, CDC6, NPAT and P107, etc. Additionally, cyclin E plays an important role in the regulation of genomic stability, spindleorganizing structure and centrosome cycle. Cyclin E expression is transactivated by members of the transcription factor E2F family and degrades via the ubiquitinproteasome pathway.  At the same time, it is also negatively regulated by the CIP/KIP proteins. Cyclin E highly expressed in the initiation and progression of different human cancers, such as breast cancers, lung cancers, leukemia, lymphomas and others.

关键词: 细胞周期蛋白E, 细胞周期调控, 细胞周期蛋白类, 肿瘤

Abstract: Cyclin E is expressed starting from the middle G1 phase of the cell cycle, and is accumulated in the G1/S boundry. Cyclin E binds to and activates the cyclindependent kinase CDK2. Cyclin E-CDK2 complex initiates a cascade of events that leads to DNA replication by phosphorylating its substrates, such as Rb, CDC6, NPAT and P107, etc. Additionally, cyclin E plays an important role in the regulation of genomic stability, spindleorganizing structure and centrosome cycle. Cyclin E expression is transactivated by members of the transcription factor E2F family and degrades via the ubiquitinproteasome pathway.  At the same time, it is also negatively regulated by the CIP/KIP proteins. Cyclin E highly expressed in the initiation and progression of different human cancers, such as breast cancers, lung cancers, leukemia, lymphomas and others.

Key words: Cyclin E, Cell cycle regulation, Cyclins, Neoplasms