国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (2): 111-113.

• 综述 • 上一篇    下一篇

乳酸与肿瘤

赵士艳, 黄钢   

  1. 200127 上海交通大学医学院附属仁济医院核医学科
  • 出版日期:2012-02-08 发布日期:2012-01-18
  • 通讯作者: 黄钢,Email:huang2802@163.com E-mail:huang2802@163.com

Lactate and tumor

ZHAO  Shi-Yan, HUANG  Gang   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2012-02-08 Published:2012-01-18
  • Contact: Corresponding author: HUANG Gang, E-mail: huang2802@163.com E-mail:huang2802@163.com

摘要: 乳酸被认为是糖酵解的最终代谢废物。肿瘤内乳酸的产生和堆积能促进肿瘤的生长和转移,且与肿瘤的预后不良有关。而最近研究发现,肿瘤细胞也可以摄取和利用乳酸。随着肿瘤代谢和基因治疗的发展,已发现乳酸是十分有价值的肿瘤治疗靶点。

关键词: 肿瘤, 碳水化合物, 治疗

Abstract: Lactate is considered a dead-end product of glycolysis. Its generation and accumulation promotes tumor growth and metastasis, and it is related to the poor prognosis of tumor. But recent studies have found, tumor cells can also uptake and utilize lactate. With the recent advances in tumor metabolism and gene therapy, lactate is a potential therapeutic target in tumors.