放射性核素治疗肿瘤的机制及其在胶质瘤中的研究进展

doi:10.3760/cma.j.cn371439-20250530-00123

摘要/Abstract

摘要：

胶质瘤，尤其是胶质母细胞瘤，是一类预后极差的中枢神经系统恶性肿瘤。近年来，放射性核素在胶质瘤的诊疗中展现出独特优势。放射性核素治疗通过利用放射性同位素释放的粒子实现对肿瘤细胞的精准杀伤，并通过多样化的递送系统跨越血脑屏障，进一步实现精准放疗。然而，目前尚缺乏针对胶质瘤干细胞精准打击及放射免疫联合策略的研究。伴随着研究的深入，放射性核素治疗有望突破现有治疗瓶颈，为胶质瘤的综合治疗提供新的方向。

关键词: 放射性同位素, 神经胶质瘤, 放射性核素受体靶向治疗

Abstract:

Glioma， particularly glioblastoma， is a type of highly malignant central nervous system tumors with extremely poor prognoses. In recent years， radionuclides have demonstrated unique advantages in the diagnosis and treatment of gliomas. Radionuclide therapy enables precise tumor cell eradication through the emission of radioactive particles， and further achieves precise radiotherapy by crossing the blood-brain barrier through diverse delivery systems. However， at present， there is a lack of research on precise targeting of glioma stem cells and the combined strategy of radiotherapy and immunotherapy. As research continues to advance， radionuclide therapy holds promise for breaking through the existing therapeutic limitations and offering new directions for the comprehensive treatment of gliomas.

Key words: Radioisotopes, Glioma, Receptor-targeted radionuclide therapy

廖智鹏, 何咏霖, 杜爱超, 潘亚文. 放射性核素治疗肿瘤的机制及其在胶质瘤中的研究进展[J]. 国际肿瘤学杂志, 2025, 52(11): 720-725.

Liao Zhipeng, He Yonglin, Du Aichao, Pan Yawen. Mechanisms of radionuclide therapy for tumors and research advances in gliomas[J]. Journal of International Oncology, 2025, 52(11): 720-725.

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