广泛期小细胞肺癌胸部放疗研究进展

doi:10.3760/cma.j.cn371439-20200707-00046

摘要/Abstract

摘要：

广泛期小细胞肺癌(ES-SCLC)预后差,生存期短。尽管铂类和依托泊苷组成的全身治疗方案以及预防性颅脑照射已经成为ES-SCLC的治疗方案,但仍面临着局部控制率和总体生存率低的挑战。放疗作为局部治疗手段,适用范围广,不仅可用于局部病变的根治性治疗,对晚期患者也可选择性地实施姑息治疗。胸部放疗可以改善ES-SCLC的局部控制,其中化疗后残留胸腔内病灶的患者受益最大。联合胸部放疗的适宜人群、放疗最佳剂量以及放疗分割方式目前尚无统一标准,仍需进一步研究。

关键词: 小细胞肺癌, 放射疗法, 广泛期

Abstract:

Extensive stage small cell lung cancer (ES-SCLC) has a poor prognosis and short survival. Although platinum based combined with etoposide regimens and prophylactic craniocerebral irradiation have become the treatment regimens for ES-SCLC, it still faces the challenges of low local control rate and overall survival rate. As a local treatment, radiotherapy has a wide range of applications, which can not only be used for the radical treatment of local lesions, but also for the selective palliative treatment of advanced patients. Thoracic radiotherapy can improve the local control of ES-SCLC, among them, patients with residual intrathoracic lesions after chemotherapy benefit the most. There is still no unified standard for the appropriate population, optimal dose and segmentation of thoracic radiotherapy, and further research is needed.

Key words: Small cell lung carcinoma, Radiotherapy, Extensive stage

武志, 杨光, 李琳, 张强. 广泛期小细胞肺癌胸部放疗研究进展[J]. 国际肿瘤学杂志, 2021, 48(4): 231-234.

Wu Zhi, Yang Guang, Li Lin, Zhang Qiang. Advances in thoracic radiotherapy for extensive stage small cell lung cancer[J]. Journal of International Oncology, 2021, 48(4): 231-234.

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