国际肿瘤学杂志 ›› 2020, Vol. 47 ›› Issue (6): 372-376.doi: 10.3760/cma.j.cn371439-20191206-00039

• 综述 • 上一篇    下一篇

细胞铁死亡调控机制及其在乳腺癌治疗中的意义

徐一月, 赵少荣, 刘晶晶, 张瑾()   

  1. 天津医科大学肿瘤医院乳腺肿瘤三科 国家肿瘤临床医学研究中心 天津市“肿瘤防治”重点实验室 天津市恶性肿瘤临床医学研究中心 300060
  • 收稿日期:2019-12-06 修回日期:2019-12-19 出版日期:2020-06-08 发布日期:2020-07-22
  • 通讯作者: 张瑾 E-mail:zhangjintjmuch1@163.com
  • 基金资助:
    国家自然科学基金(81672623)

Mechanisms of ferroptosis and its significance in breast cancer therapy

Xu Yiyue, Zhao Shaorong, Liu Jingjing, Zhang Jin()   

  1. Third Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Clinical Research Center for Cancer of Tianjin, Tianjin 300060, China
  • Received:2019-12-06 Revised:2019-12-19 Online:2020-06-08 Published:2020-07-22
  • Contact: Zhang Jin E-mail:zhangjintjmuch1@163.com
  • Supported by:
    National Natural Science Foundation of China(81672623)

摘要:

乳腺癌是起源于乳腺上皮组织的恶性肿瘤,铁死亡是一种新发现的、不同于细胞凋亡和坏死的细胞程序性死亡方式。目前研究表明,脂质过氧化物在细胞内的堆积这一铁死亡诱发的关键过程可由多种机制诱发,铁死亡的调控与乳腺癌的发生、发展密切相关,药物诱导乳腺癌细胞铁死亡是颇具潜力与价值的研究方向。

关键词: 乳腺肿瘤, 活性氧, 铁死亡

Abstract:

Breast cancer is a malignant tumor originating from breast epithelial tissue. Ferroptosis is a novel type of programmed cell death which differs from apoptosis and necrosis. Research found that the accumulation of lipid peroxides in cells, a crucial process of ferroptosis, can be induced by multiple mechanisms. The ferroptosis regulation is closely related to the occurrence and development of breast cancer, and it induced by drugs is a potential and valuable research direction in breast cancer.

Key words: Breast neoplasms, Reactive oxygen species, Ferroptosis