国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 626-628.doi: 10.3760/cma.j.issn.1673-422X.2017.08.018

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反转录病毒结合位点1基因在急性淋巴细胞性白血病中的

陆娇,刘丹丹   

  1. 215000苏州大学附属第一医院血液科 江苏省血液研究所 国家卫生和计划生育委员会血栓与止血重点实验室
  • 出版日期:2017-08-08 发布日期:2017-07-21
  • 通讯作者: 刘丹丹，Email: liudd_2006@126.com E-mail: liudd_2006@126.com
  • 基金资助:

    国家自然科学基金（81300424）；江苏省自然科学基金（BK20151231）

Advances of ecotropic viral integration site 1 gene in acute lymphoblastic leukemia

Lu Jiao, Liu Dandan   

  1. Department of Hematology, First Affiliated Hospital of Soochow University; Jiangsu Institute of Hematology; Key Laboratory of Thrombosis and Hemostasis, National Health and Family Planning Commission of the People′s Republic of China, Suzhou 215000, China
  • Online:2017-08-08 Published:2017-07-21
  • Contact: Liu Dandan, Email: liudd_2006@126.com E-mail: liudd_2006@126.com
  • Supported by:

    National Natural Science Foundation of  China (81300424); Natural Science Foundation of Jiangsu Province of China (BK20151231)

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摘要： 作为原癌基因，反转录病毒结合位点1（EVI1）基因在急性髓系白血病（AML）中可因染色体易位或其他遗传学异常而高表达，最终导致预后较差。近年来，EVI1基因在急性淋巴细胞性白血病（ALL）中的研究逐渐增多，尤其在儿童ALL中的研究较多。EVI1基因高表达亦提示预后不良，且与年龄密切相关，但是其与混合谱系白血病（MLL）基因重排及BCRABL基因重排的关系有待进一步研究。研究ALL中EVI1基因的表达特点以及探索相应的靶向治疗药物是今后的重要研究方向。

关键词: 原癌基因, 白血病, 淋巴样, 基因表达, 反转录病毒结合位点-1基因

Abstract: As an proto-oncogene, ecotropic viral integration site 1 (EVI1) gene is overexpressed in acute myeloid leukemia (AML) because of chromosomal translocation or other genetic abnormalities, finally cause poor prognosis. In recent years, an increasing research of the expression of EVI1 in acute lymphoblastic leukemia (ALL), especially in pediatric ALL. The overexpression of EVI1 gene also suggest a poor prognosis, which is closely relate to the age. But the relationship between the expression of EVI1 gene and mixed lineage leukemia (MLL) and BCRABL gene rearrangement needs to be further studied. Researching the expression of EVI1 gene in ALL and exploring targeted therapeutic agents are important research directions in the future.

Key words: Protooncogene, Leukemia, lymphoid, Gene expression, Ecotropic viral integration site 1 gene