国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 629-632.doi: 10.3760/cma.j.issn.1673-422X.2017.08.019

• 综述 • 上一篇    下一篇

微小RNA与弥漫大B细胞淋巴瘤的关系及其作用

王馨辰, 丁凯阳   

  1. 230001 合肥，安徽医科大学附属省立医院血液科
  • 出版日期:2017-08-08 发布日期:2017-07-21
  • 通讯作者: 丁凯阳，Email: dingkaiy@126.com E-mail:dingkaiy@126.com
  • 基金资助:

    安徽省自然科学基金（1608085MH228）

Relationship between microRNAs and diffuse large B-cell lymphoma and its effect

Wang Xinchen, Ding Kaiyang   

  1. Department of Hematology, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China
  • Online:2017-08-08 Published:2017-07-21
  • Contact: Ding Kaiyang, Email: dingkaiy@126.com E-mail:dingkaiy@126.com
  • Supported by:

    Natural Science Foundation of Anhui Province of China (1608085MH228)

PDF

790

摘要： 弥漫大B细胞淋巴瘤（DLBCL）是最常见的非霍奇金淋巴瘤，具有高度异质性。研究表明，微小RNA（miRNA）参与调控众多生物过程，与淋巴造血系统密切相关，并且在B细胞分化各阶段及其恶性转化过程中发挥重要作用。miRNA作为一种潜在的生物标志物日益受到关注，它与DLBCL的分型密切相关，对于该病的诊断具有重要价值，同时有助于判断不同患者的预后，并且可能成为新的治疗靶点。

关键词: 淋巴瘤, 大B细胞, 弥漫性, 微RNAs

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common nonHodgkin lymphoma with a high degree of heterogeneity. Studies have  shown that microRNAs (miRNAs) are involved in many biological processes and are closely related to lymphoid hematopoietic system and play an important role in various stages of B-cell differentiation and malignant transformation. miRNAs are increasingly concerned as a potential biomarker, which are closely related to the classification of DLBCL. miRNAs are of great values for the diagnosis of the disease and help to determine the prognosis of different patients, which may become new therapeutic targets.

Key words: Lymphoma, large-B cell, diffuse, MicroRNAs