放疗协同免疫检查点阻滞剂治疗肿瘤的机制

doi:10.3760/cma.j.issn.1673422X.2017.03.013

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (3): 209-212.doi: 10.3760/cma.j.issn.1673422X.2017.03.013

放疗协同免疫检查点阻滞剂治疗肿瘤的机制

陈泽宏,苏如雄,杨子科,康世均

510515 广州，南方医科大学中西医结合医院肿瘤科（陈泽宏、杨子科）；南方医科大学附属普宁市人民医院药剂科（苏如雄）；南方医科大学南方医院肿瘤科（康世均）

出版日期:2017-03-08 发布日期:2017-02-28
通讯作者: 康世均 E-mail:junekfm@yahoo.com
基金资助:
国家自然科学基金（81372449）

Mechanisms of cancer treatment by radiotherapy combined with immune checkpoint blockade

Chen Zehong, Su Ruxiong, Yang Zike, Kang Shijun

Department of Oncology, Traditional Chinese MedicineIntegrated Hospital, Southern Medical University, Guangzhou 510515, China

Online:2017-03-08 Published:2017-02-28
Contact: Kang Shijun E-mail:junekfm@yahoo.com
Supported by:
National Natural Science Foundation of China

(81372449)

摘要/Abstract

摘要： 随着对肿瘤免疫机制的深入研究，学者们注意到了放疗激活机体产生全身免疫效应的现象，改变了放疗是“免疫抑制性”的片面认识。然而，放疗虽能增强机体的抗肿瘤免疫，在临床上，接受放疗的患者仍避免不了复发、转移。研究表明，这与肿瘤微环境诱导的免疫检查点通路异常激活密切相关。因此，将放疗与免疫检查点阻滞剂联合应用，改善肿瘤微环境，能提高肿瘤治疗效果。

关键词: 放射疗法, 肿瘤逃逸, 免疫检查点阻滞剂

Abstract: With the further researches on the immune mechanisms in tumor, more and more scholars notice the phenomenon that radiation activates the immunity, and find that "radiotherapy causes immunity suppression" is onesided. Although body′s antitumor immunity can be enhanced by radiotherapy, in clinical, we observe that patients who receive radiotherapy cannot avoid tumor recurrence and metastasis. Researches show that tumor microenvironment makes the immune checkpoint pathway abnormally activated. Therefore, the combination of radiotherapy and immune checkpoint inhibitor can change the tumor microenvironment, and can improve the therapeutic effect.

Key words: Radiotherapy, Tumor escape, Immune checkpoint blockade

陈泽宏,苏如雄,杨子科,康世均. 放疗协同免疫检查点阻滞剂治疗肿瘤的机制[J]. 国际肿瘤学杂志, 2017, 44(3): 209-212.

Chen Zehong, Su Ruxiong, Yang Zike, Kang Shijun. Mechanisms of cancer treatment by radiotherapy combined with immune checkpoint blockade[J]. Journal of International Oncology, 2017, 44(3): 209-212.

参考文献

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放疗协同免疫检查点阻滞剂治疗肿瘤的机制

Mechanisms of cancer treatment by radiotherapy combined with immune checkpoint blockade

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