miR-139抗肿瘤作用与机制

doi:10.3760/cma.j.issn.1673-422X.2016.10.010

摘要/Abstract

摘要： 微小RNA（miRNA）与肿瘤的发生发展密切相关。miR139是一种具有抑癌作用的miRNA分子，在多种肿瘤组织中表达降低，而过表达miR-139可通过多种靶基因抑制肿瘤细胞的增殖、迁移和侵袭，并诱导其凋亡。因此，miR139在肿瘤的临床诊断、治疗及预后判断等方面具有潜在的应用前景。

关键词: 微RNAs, 肿瘤, 靶基因

Abstract: MicroRNA (miRNA) is closely related to the occurrence and development of neoplasms. miR139 is a tumorsuppressive miRNA and its expression is decreased in a variety of tumor tissues, while overexpression of miR139 can inhibit cancer cell proliferation, migration, invasion and induce cell apoptosis by suppressing the expression of multiple kinds of target genes. Therefore, miR139 has potential applications in tumor diagnosis, treatment and prognosis assessment.

Key words: MicroRNAs, Neoplasms, Target gene

翟俊山,李楠. miR-139抗肿瘤作用与机制[J]. 国际肿瘤学杂志, 2016, 43(10): 765-768.

Zhai Junshan, Li Nan. Anticancer effect and mechanism of miR-139[J]. Journal of International Oncology, 2016, 43(10): 765-768.

参考文献

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