国际肿瘤学杂志 ›› 2023, Vol. 50 ›› Issue (3): 183-185.doi: 10.3760/cma.j.cn371439-20221103-00036

• 综述 • 上一篇    下一篇

血脂水平与胃癌的相关性

姬薇1, 关泉林2(), 陈雅蕊1, 焦福智1, 罗倩文1   

  1. 1兰州大学第一临床医学院,兰州 730000
    2兰州大学第一医院肿瘤外科,兰州 730000
  • 收稿日期:2022-11-03 修回日期:2022-11-17 出版日期:2023-03-08 发布日期:2023-04-12
  • 通讯作者: 关泉林,Email: guanql@lzu.edu.cn
  • 基金资助:
    甘肃省重点研究计划(2017YFC0908302)

Correlation between blood lipid level and gastric cancer

Ji Wei1, Guan Quanlin2(), Chen Yarui1, Jiao Fuzhi1, Luo Qianwen1   

  1. 1First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
    2Department of Oncology Surgery, First Hospital of Lanzhou University, Lanzhou 730000, China
  • Received:2022-11-03 Revised:2022-11-17 Online:2023-03-08 Published:2023-04-12
  • Contact: Guan Quanlin, Email: guanql@lzu.edu.cn
  • Supported by:
    Key Research Program of Gansu Province of China(2017YFC0908302)

摘要:

胃癌患者常存在不同程度的血脂异常,且血脂变化与胃癌发生、发展及预后密切相关。胃癌中血脂代谢的机制也备受关注,可能与高密度脂蛋白胆固醇逆向转运胆固醇功能、抗氧化抗炎特性等机制有关。此外,他汀类药物或可降低患胃癌的风险及相关死亡率。进一步研究血脂水平与胃癌的相关性,旨在为未来胃癌预防与精准诊疗提供新的思路。

关键词: 胃肿瘤, 血脂异常, 羟甲基戊二酰基CoA还原酶抑制剂

Abstract:

Patients with gastric cancer often have different degrees of dyslipidemia, and the level of lipid changes is closely related to the occurrence, development and prognosis of gastric cancer. The mechanism of lipid metabolism in gastric cancer has also attracted much attention, and it may be related to the reverse cholesterol transport function, antioxidant and anti-inflammatory properties of high-density lipoprotein cholesterol. In addition, statins may reduce the risk of gastric cancer and associated mortality. Further research on the correlation between blood lipid levels and gastric cancer is aimed to provide new ideas for the future prevention and precision diagnosis and treatment of gastric cancer.

Key words: Stomach neoplasms, Dyslipidemia, Hydroxymethylglutaryl-CoA reductase inhibitors