CTHRC1在消化系统肿瘤中的研究进展

doi:10.3760/cma.j.issn.1673-422X.2016.05.016

摘要/Abstract

摘要： 胶原三股螺旋重复蛋白1(CTHRC1)基因主要是通过抑制胶原的沉积及促进细胞的迁移，参与受损血管的修复，主要受WntPCP信号通路、转化生长因子骨成型蛋白(TGFBMP)信号通路和胞外信号调节酶基质金属蛋白酶9(ERKMMP9)信号通路调控。近年来发现CTHRC1在多种消化系统肿瘤中存在异常表达，并且参与了肿瘤的发生与发展。

关键词: 消化系统肿瘤, 基因, 胶原三股螺旋重复蛋白1

Abstract: Collagen triple helix repeat containing 1 (CTHRC1) can repair the injured vessel by limiting the deposition of collagen and promoting cell migration. CTHRC1 is mainly regulated by WntPCP signaling pathway， transforming growth factor (TGF)bone morphogenetic protein (BMP) signaling pathway and extracellular signalregulated kinase (ERK)matrix metalloproteinase 9 (MMP9) signaling pathway. Recent studies have identified that CTHRC1 is aberrantly expressed in gastrointestinal cancers and associated with the occurring and development of cancers.

Key words: Digestive system neoplasms, Genes, Collagen triple helix repeat containing 1

汪妍,王潞,丰江舟,李登. CTHRC1在消化系统肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2016, 43(5): 382-384.

Wang Yan, Wang Lu, Feng Jiangzhou, Li Deng. Research progress of CTHRC1 in gastrointestinal cancers[J]. Journal of International Oncology, 2016, 43(5): 382-384.

参考文献

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