国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 569-572.doi: 10.3760/cma.j.issn.1673422X.2015.08.003

• 论著 • 上一篇    下一篇

凋亡相关蛋白Bcl2和Bax在基底细胞样乳腺癌中的表达及意义

张丙信, 赵霞, 贾喜花, 陈雪, 陈红, 马秋双, 张金库   

  1. 071000保定市第一中心医院病理科（张丙信、陈雪、陈红、马秋双、张金库），肿瘤内科（赵霞、贾喜花）
  • 出版日期:2015-08-08 发布日期:2015-06-29
  • 通讯作者: 张金库，Email：2286917939@qq.com E-mail:2286917939@qq.com

Expressions and significances of apoptosis related protein Bcl2 and Bax in basallike breast carcinoma

 ZHANG  Bing-Xin, ZHAO  Xia, JIA  Xi-Hua, CHEN  Xue, CHEN  Hong, MA  Qiu-Shuang, ZHANG  Jin-Ku   

  1. Department of Medical Pathology, First Central Hospital of Baoding, Baoding 071000, China
  • Online:2015-08-08 Published:2015-06-29
  • Contact: Zhang Jinku E-mail:2286917939@qq.com

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摘要： 目的探讨Bcl2和Bax蛋白在基底细胞样乳腺癌(BLBC)中的表达及意义。 方法免疫组织化学法检测43例BLBC、57例非基底细胞样乳腺癌 (nonBLBC)、60例正常乳腺组织中Bcl2和Bax蛋白的表达，分析其与患者生理病理的关系。 结果Bcl2在BLBC中的表达率为69.77%，高于nonBLBC的43.86%（χ2=6.647, P=0.010）和正常乳腺组织的21.67%（χ2=23.831, P=0.001）；Bax在BLBC中的表达率为20.93%，低于nonBLBC的45.61%（χ2=6.564, P=0.010）和正常乳腺组织的76.67%（χ2=31.270, P=0.001）。Bcl2和Bax在BLBC中的表达水平与淋巴结转移（χ2=6.927, P=0.008; χ2=6.203, P=0.013）及pTNM分期（χ2=6.331, P=0.012; χ2=5.972, P=0.015）相关。Bcl2与Bax在BLBC中的表达呈负相关（r=-0.408, P＜0.010）。 结论Bcl2和Bax分别在BLBC中高表达和低表达，两者可能共同作用使细胞增殖与凋亡平衡失调，从而促进了BLBC的发生、发展。

关键词: 乳腺肿瘤, 原癌基因蛋白质cbcl2, Bax

Abstract: ObjectiveTo investigate the expressions and significances of Bcl2 and Bax in basallike breast carcinoma (BLBC). MethodsThe expressions of Bcl2 and Bax were detected in 43 cases of BLBC, 57 cases of nonBLBC and 60 cases of normal breast tissues by immunohistochemistry, and their relationships with physiological and pathological characteristics of patients were analysized. ResultsThe positive rate of Bcl2 in BLBC was 69.77%, higher than 43.86% in nonBLBC (χ2=6.647, P=0.010) and 21.67% in normal breast tissues (χ2=23.831, P=0.001). The positive rate of Bax in BLBC was 20.93%, lower than 45.61% in nonBLBC (χ2=6.564, P=0.010) and 76.67% in normal breast tissues (χ2=31.270, P=0.001). The expressions of Bcl2 and Bax were correlated with lymphnode metastasis (χ2=6.927, P=0.008; χ2=6.203, P=0.013) and pTNM staging of BLBC (χ2=6.331, P=0.012; χ2=5.972, P=0.015). There was negative correlation between the expression of Bcl2 and Bax in BLBC (r=-0.408, P＜0.010). ConclusionHigh expression of Bcl2 and low expression of Bax interact with each other leading to unbalance of cell deferation and apoptosis, resulting in promoting genesis and progress of BLBC.

Key words: Breast neoplasms, Protooncogene proteins cbcl2, Bax