国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (11): 851-854.doi: 10.3760/cma.j.issn.1673-422X.2014.11.016

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白血病髓外浸润相关微环境王慧石军

  

  1. 上海交通大学附属第六人民医院血液科
  • 出版日期:2014-12-03 发布日期:2015-01-20
  • 通讯作者: 石军, Email:shijun7@hotmail.com
  • 基金资助:

    国家自然科学基金(81170507);上海市科委课题(13DZ2293702)

Microenvironment for leukemia extramedullary infiltration

  1. Department of Hematology, Affiliated Sixth People′s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2014-12-03 Published:2015-01-20
  • Contact: Shi Jun, Email: shijun7@hotmail.com

摘要: 白血病细胞的髓外组织浸润是导致白血病患者复发、死亡的重要原因之一,越来越多的研究显示髓外微环境在白血病进展和复发中发挥重要作用。白血病髓外浸润的发生是多因素、多步骤相互作用的结果,涉及肝、脾、中枢神经系统、胸腺等各组织器官。

关键词: 白血病, 白血病浸润, 复发, 髓外微环境

Abstract: Extramedullary infiltration is one of the reasons of relapse and death for leukemia patients. Reaearches increasingly show that extramedullary microenvironment plays a pivotal role on progress and relapse of leukemia. Extramedullary infiltration of leukemia is the result of interactions among many factors and many steps, involving liver, spleen, central nervous system, thymus and other tissues and organs.

Key words: Leukemia, Leukemic infiltration, recurrence, Extramedullary microenvironment