国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (7): 415-419.doi: 10.3760/cma.j.issn.1673-422X.2019.07.005

• 论著 • 上一篇    下一篇

深圳市2001—2015年白血病流行特征和时间趋势

雷林1吉勇2尚庆刚1彭绩1任骅3，4   

  1. 1深圳市慢性病防治中心518020； 2国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院深圳医院医务部，深圳518116； 3国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院放疗科，北京100021； 4国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院深圳医院放疗科，深圳518116
  • 出版日期:2019-07-08 发布日期:2019-07-16
  • 通讯作者: 任骅 E-mail:renhua1973@aliyun.com

Epidemiologic features and trends of leukemia in Shenzhen during 2001-2015

Lei Lin1, Ji Yong2, Shang Qinggang1, Peng Ji1, Ren Hua3,4   

  1. 1Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China; 2Department of Medical Administration, Shenzhen Hospital of Cancer Hospital, National Cancer Center, National Center for Oncology Clinical Medical Research, Chinese Academy of Medical Sciences, Peking Union Medical College, Shenzhen 518116, China; 3Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China; 4Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China
  • Online:2019-07-08 Published:2019-07-16
  • Contact: Ren Hua E-mail:renhua1973@aliyun.com

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摘要： 目的探讨2001—2015年深圳居民白血病的发病趋势，为制定深圳市白血病的预防和控制政策提供基础依据。方法根据深圳市肿瘤发病登记处收集的2001—2015年户籍居民白血病发病数据和相应年份的人口资料，计算白血病粗发病率以及标准化人口年龄调整的发病率（简称标化发病率）即中国人口标化率（简称中标率）和世界人口标化率（简称世标率），利用Joinpoint软件进行趋势分析。结果2001—2015年深圳市肿瘤登记处共登记白血病2 106例，粗发病率为6.31/10万，中标率为6.75/10万，世标率为7.15/10万，0~74岁累积率为0.63%，35~64岁截缩率为7.03/10万。从性别分布来看，男性标化发病率明显高于女性，男女发病比为1.38∶1。从时间趋势上看，白血病发病率较为稳定，通过Joinpoint回归分析显示，世标率年度发病变化百分比（APC）为-0.09%（95%CI为-1.60%~1.41%，P=0.92）。从不同亚型看，急性髓细胞白血病(AML)占所有白血病的17.66%，且发病率呈现上升趋势，APC为13.34%（95%CI为5.71%~21.51%，P<0.01）。白血病患者的中位发病年龄为36岁，平均年龄为37.29岁。发病率有1~4岁组和80~84岁组两个高峰，其发病率分别为9.13/10万和39.40/10万。结论深圳为白血病的高发地区，儿童和老年人是白血病的高发人群，政府部门需引导相关机构开展研究，降低白血病的发病率。

关键词: 白血病, 发病率, 时间趋势, 肿瘤登记

Abstract: ObjectiveTo describe the incidence trend of leukemia in Shenzhen during 2001 to 2015, and to provide base data for designing prevention and treatment strategies on leukemia. MethodsThe leukemia incidence data and population data collected by Shenzhen Cancer Registry from 2001 to 2015 were used in our analysis. The crude incidence, agestandardized incidence rate by Chinese standard population (ASR China) and agestandardized incidence rate by world standard population (ASR world) were calculated. The annual percentage change (APC) of the incidence was analyzed by Joinpoint regression. ResultsShenzhen Cancer Registry registered 2 106 new cases of leukemia from 2001 to 2015. The crude incidence was 6.31 per 100 000, with 6.75 per 100 000 ASR China and 7.15 per 100 000 ASR world. Cumulative rate (074 years) was 0.63%, and truncated rate (3564 years) was 7.03 per 100 000. From the perspective of gender distribution, the incidence of male was significantly higher than female, with a sex ratio of 1.38∶1. In terms of time trend, the incidence of leukemia was stable, and the Joinpoint regression showed that APC=-0.09%(95%CI: -1.60%1.41%, P=0.92). In terms of subtypes, acute myelocytic leukemia (AML) accounted for 17.66% of the total cases, and the incidence of AML has increased during 2001 to 2015 (APC=13.34%, 95%CI: 5.71%21.51%, P<0.01). The median age of leukemia patients was 36 years old, and the mean age was 37.29 years old. The two peaks of the incidence were 14 and 8084 age groups, and the ASR incidences were 9.13 per 100 000 and 39.40 per 100 000 respectively. ConclusionThe incidence of leukemia is very high in Shenzhen. Children and the elderly are at high risk of leukemia. Government needs to guide institutions to carry out research to reduce the incidence of leukemia.

Key words: Leukemia, Incidence, Time trend, Cancer register