国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 665-668.

• 综述 • 上一篇    下一篇

原癌基因Bmi-1与头颈部恶性肿瘤

高珊, 王仁生   

  1. 530021南宁，广西医科大学第一附属医院放疗科
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 王仁生，E-mail: wrsgx@yahoo.com.cn E-mail:wrsgx@yahoo.com.cn

Proto-oncogene Bmi-1 and head and neck cancer

GAO  Shan, WANG  Ren-Sheng   

  1. Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning530021, China
  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: WANG Ren-sheng, E-mail: wrsgx@yahoo.com.cn E-mail:wrsgx@yahoo.com.cn

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摘要： Bmi-1基因是多梳基因家族的核心成员之一。作为一种原癌基因，Bmi-1基因在细胞的自我更新、增殖及凋亡方面发挥重要作用。多项研究已证实，Bmi-1基因在鼻咽癌、喉癌等多种头颈部恶性肿瘤中均有异常表达，并与肿瘤的发生、发展、侵袭、预后密切相关。Bmi-1基因有望成为一种新的肿瘤分子标志物，为头颈部恶性肿瘤的诊断、治疗提供新的方向和手段。

关键词: 基因, 头颈部肿瘤, Bmi-1

Abstract: Bmi-1 is a core member of the polycomb group genes. As a proto-oncogene, Bmi-1 plays an important role in cell self-renewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in some head and neck malignant tumors, such as nasopharyngeal cancer and laryngeal carcinoma.  Furthermore, the expression level of Bmi-1 is closely related to the occurrence, development, incursion and prognosis of tumor. Bmi-1 is expected to become a novel tumor molecular marker, and provides a new direction for the treatment of the head and neck malignant tumor.

Key words: Genes, Head and neck neoplasms, Bmi-1