国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 542-546.

• 综述 • 上一篇    下一篇

乏氧及Notch1在多发性骨髓瘤中作用的研究进展

李斑斑, 郭冬梅, 滕清良   

  1. 271000 山东省泰安市中心医院血液内科
  • 出版日期:2013-07-08 发布日期:2013-07-08
  • 通讯作者: 滕清良，E-mail: tatql@163.com E-mail:tatql@163.com
  • 基金资助:

    山东省自然科学基金（2009ZRA09006）；山东省医药卫生科技发展计划项目（2011HW077）

Roles of hypoxia and Notch1 in multiple myeloma 

LI  Ban-Ban, GUO  Dong-Mei, TENG  Qing-Liang   

  1. Department of Hematology, Tai’an Central Hospital, Tai’an 271000, China
  • Online:2013-07-08 Published:2013-07-08
  • Contact: TENG Qing-Liang E-mail:tatql@163.com

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被引次数

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摘要： 多发性骨髓瘤(MM)存在明显的骨髓乏氧微环境，骨髓高表达乏氧诱导因子-1α(HIF-1α)，其与预后不良相关。Notch信号通路是造血微环境中调控细胞增殖与分化的重要信号转导系统，与多发性骨髓瘤的发生和耐药有关。新近研究显示乏氧与Notch通路在多种恶性肿瘤发生发展中存在密切联系。乏氧微环境、HIF-1α及Notch相关信号通路的相互作用为开拓MM分子靶向治疗提供理论依据。

关键词: 细胞低氧, 缺氧诱导因子1, α亚基, 多发性骨髓瘤, 受体, Notch1

Abstract: Recently numerous studies have demonstrated that in multiple myeloma (MM) hypoxia obviously exists the microenvironment of hypoxia, in which there is overexpression of hypoxia-inducible transcription factor-1α (HIF-1α) that is related to poor prognosis. Notch signaling pathway plays a critical role in regulating cell proliferation and differentiation in hematopoietic microenvironment, which is associated with MM occurrence and the drug resistance. The latest researches show that there are close relations between hypoxia and Notch signaling pathway in tumor occurrence and progression. Exploring the interactions of microenvironment of hypoxia, HIF-1α and Notch signaling pathway will provide theoretical basis for MM targeted therapy.

Key words: Cell hypoxia, Hypoxia-inducible factor 1, alpha subunit, Multiple myeloma, Receptor, Notch1