国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 489-491.

• 综述 • 上一篇    下一篇

甲状旁腺素相关肽与肿瘤

杨明妍, 梁华晟   

  1. 536000广西北海内分泌代谢研究所
  • 出版日期:2013-07-08 发布日期:2013-07-08
  • 通讯作者: 梁华晟,E-mail: Flowchaos@yahoo.com.cn E-mail:Flowchaos@yahoo.com.cn
  • 基金资助:

    北海市科学研究与技术开发项目(200901059)

Parathyroid hormone related peptide and tumor 

YANG  Ming-Yan, LIANG  Hua-Sheng   

  1. Institute of Endocrine and Metabolic Diseases, Guangxi Beihai, Beihai 536000, China
  • Online:2013-07-08 Published:2013-07-08
  • Contact: LIANG Hua-Sheng E-mail:Flowchaos@yahoo.com.cn

摘要: 甲状旁腺素相关肽(PTHrP)参与调节钙磷代谢和多器官的生长发育,在恶性肿瘤发生骨转移和高钙血症过程中发挥重要作用。目前越来越多的研究证实PTHrP可以由多种类型的肿瘤细胞分泌,参与调节肿瘤细胞的增殖、侵袭,并与患者预后密切相关,为肿瘤治疗提供了新的靶点。

关键词: color: black, font-size: 12pt, mso-bidi-font-family: 宋体, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA">肿瘤, 高钙血症, 肿瘤转移, 甲状旁腺素相关肽

Abstract: The parathyroid hormone related peptide (PTHrP) participates in regulating calcium and phosphorus metabolism and multiple organ growth, and plays an important role in the processes of malignant tumor bone metastasis and hypercalcemia. Currently, more and more researches have confirmed that PTHrP can be secreted by a variety of types of tumor cells. PTHrP participates in regulating tumor cell proliferation and invasion, and it is closely related to the prognosis of patients, which provides a new target of cancer treatment.

Key words: Neoplasms, Hypercalcemia, Neoplasm metastasis, Parathyroid hormone related peptide