国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (4): 302-306.

• 论著 • 上一篇    下一篇

不同生存期鼻咽癌放疗疗效的对比研究

徐志渊, 林连兴   

  1. 515031 广东省汕头市中心医院肿瘤放疗科
  • 出版日期:2013-04-08 发布日期:2013-03-27

A comparative study on nasopharyngeal carcinoma treated by radiotherapy with different survival time

XU  Zhi-Yuan, LIN  Lian-Xing   

  1. Shantou Central Hospital，Shantou 515031，China
  • Online:2013-04-08 Published:2013-03-27

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摘要： 目的 了解放疗后不同生存期鼻咽癌的临床特征,为鼻咽癌的临床治疗提供帮助。方法 回顾性分析2000年1月至2002年4月收治的353例鼻咽癌患者的临床资料, 按生存时间分为3组：A组145例患者，生存期＜5年；B组16例患者，5年≤生存期＜10年；C组192例患者，生存期≥10年。比较3组的临床资料, 并分析影响预后的因素。结果 全部353例鼻咽癌患者总5年生存率为58.924%，总10年生存率54.391%。病情早期（Ⅰ期和Ⅱ期）比晚期（Ⅲ期和Ⅳ期）预后好。多因素分析表明年龄、N分期、是否合并化疗和放疗后鼻咽和颈部淋巴结肿瘤是否均达到完全缓解是预后的相关因素。结论 鼻咽癌需要合理运用综合治疗，并尽量做到早发现、早治疗，提高近期疗效和预防并发症。

关键词: 鼻咽肿瘤, 辐射损伤, 预后

Abstract: Objective  To evaluate the clinical features of nasopharyngeal carcinoma with different survival time and to analyze the factors associated with prognosis improvement. Methods Three hundred and fifty three patients with nasopharyngeal carcinoma treated in our hospital from January 2000 to April 2002 were analyzed retrospectively. They were divided into three groups based on their survival time. One hundred and forty five patients were divided into A groups whose overall survival time were less than five years. Sixteen patients were included in B group whose overall survival time were greater than or equal to five years and less than ten years, and the other one hundred and ninety two patients were divided into C groups whose overall survival time were greater than or equal to ten years. The clinical features were compared and factors associated with survival were identified. Results The 5 and 10 years overall survival rates of the 353 nasopharyngeal carcinoma patients underwent radiotherapy were 58.924% and 54.391% respectively. Curative effect of early nasopharyngeal carcinoma was better. Cox regression analysis identified age, N stage, combined with chemotherapy or not and complete remission rate of nasopharynx and neck lymph were independent prognostic factors. Conclusion For nasopharyngeal carcinoma patients, early detection, early treatment, rational comprehensive treatment and complete remission after treatment and complications prevention are important.

Key words: Nasopharyngeal neoplasms, Radiation injuries, Prognosis