国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (3): 193-195.

• 综述 • 上一篇    下一篇

胶质母细胞瘤放射治疗靶区设计现状与思考

李明焕, 孔莉, 于金明   

  1. 250117  济南，山东省肿瘤医院放射治疗科
  • 出版日期:2013-03-08 发布日期:2013-02-25

Target volume delineation for glioblastoma multiforme: current practice and advice

LI  Ming-Huan, KONG  Li, YU  Jin-Ming   

  1. Department of Radiation Oncology, Shandong Cancer Hospital, Jinan 250117, China

  • Online:2013-03-08 Published:2013-02-25

PDF

1475

被引次数

3

摘要： 胶质母细胞瘤(GBM)术后放疗大都采用MRI与CT融合影像来勾画靶区，但是否包含瘤周水肿区尚有争议。根据术后、放疗后的复发范围，不论靶区设计是否包含水肿区，大部分复发都发生在磁共振（MRI）显示增强原发肿瘤灶外2 cm之内，瘤周水肿程度与复发模式无必然关系。GBM的临床和病理特征对放化疗疗效预测和预后也有重要指导意义。GBM的靶区设计趋向于个体化，可在保证疗效同时减少治疗毒性。

关键词: 脑肿瘤, 神经胶质瘤, 放射疗法, 靶区

Abstract: The use of adjuvant external-beam RT is well established in the postoperative treatment of glioblastoma multiforme (GBM). It is consensus that target volume should be determined based on the fusion images of MRI and CT, but the inclusion of peritumoural edematous is controversial. The vast majority of recurrences occur within 2 cm of the original tumor site or “in radiation field”. There is no inevitable relation between the degree of peritumoral edema and recurrence model. The clinical and pathological characteristics may be as predictive and prognostic factors for the treatment of GBM. Target volume delineation for GBM tend to individual, which can maintain known outcomes and reduce treatment toxicity.

Key words: Brain neoplasms, Glioma, Radiotherapy, Target volume