国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (2): 111-114.

• 综述 • 上一篇    下一篇

微小RNA与乳腺癌生物学行为的关系

解永松, 李连宏   

  1. 116044 大连医科大学七年制（解永松），病理学与法医学教研室（李连宏）
  • 出版日期:2013-02-08 发布日期:2013-01-25
  • 通讯作者: 李连宏，E-mail:lilianhong@dlmedu.edu.cn E-mail:lilianhong@dlmedu.edu.cn
  • 基金资助:

    国家自然科学基金（81272430）

MicroRNA and the biological behaviour of human breast cancer

JIE  Yong-Song, LI  Lian-Hong   

  1. Seven-year Program of Dalian Medical University, Dalian 116044, China

  • Online:2013-02-08 Published:2013-01-25
  • Contact: Correspongding author: LI Lian-hong, E-mail: lilianhong@dlmedu.edu.cn E-mail:lilianhong@dlmedu.edu.cn

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摘要： 微小（miRNA）在细胞凋亡、细胞周期、甲基转移酶等多方面调控乳腺癌细胞增殖，也在微环境、上皮-间质转换、血管生成等多方面调控乳腺癌细胞转移。最近的大量研究发现，miRNA在乳腺癌组织中特异性表达，在乳腺癌细胞增殖、转移以及在乳腺癌治疗中均发挥重要作用。

关键词: 微RNAs, 乳腺肿瘤, 肿瘤转移, 细胞增殖

Abstract: MicroRNA (miRNA) controls the proliferation of breast cancer cells in many ways such as cell apotosis, cell cycle and methyltransferase. Also, it controls the metastasis of breast cancer cells in many ways such as microenvironment, epithelial-mesenchymal transition and vessel formation. Large amounts of recent studies indicate that miRNAs are specifically expressed in breast cancer tissue and play important roles in proliferation, metastasis and treatment of breast cancer.

Key words: MicroRNAs, Breast neoplasms, Neoplasm metasis, Cell proliferation