NOD2基因与原发性肝癌

doi:10.3760/cma.j.issn.1673-422X.2013.12.015

摘要/Abstract

摘要： 核苷酸结合寡聚化结构域蛋白2（NOD2）可通过识别细菌细胞壁的肽聚糖及其裂解产物胞壁酰二肽，参与宿主对病原体的免疫应答，参与调节自然免疫和特异性免疫。NOD2作为一种新发现的细胞内模式识别受体，可通过基因变异、诱发肝脏炎症反应、激活相应信号通路在原发性肝癌的发生发展中发挥重要作用。

关键词: 多态性, 单核苷酸, 癌, 肝细胞, 核苷酸结合寡聚化结构域蛋白2

Abstract: Nucleotidebinding oligomerization domain protein 2 (NOD2) involves in host immune responses to pathogens and regulates natural immunity and specific immunity by identifying the peptidoglycan of bacterial cell walls and cleavage product muramyl dipeptide. As a newly discovered intracellular pattern recognition receptor, NOD2 plays important roles in the development of primary hepatocellular carcinoma by gene mutate, inducing liver inflammatory reaction and activating relevant signaling pathways.

Key words: Polymorphism, single nucleotide, Carcinoma, hepatocellular, Nucleotide-binding oligomerization domain protein 2

梁宁, 乔丽丽, 谢健, 张建东. NOD2基因与原发性肝癌[J]. 国际肿瘤学杂志, 2013, 40(12): 927-929.

LIANG Ning, QIAO Li-Li, XIE Jian, ZHANG Jian-Dong. NOD2 gene and primary hepatocellular carcinoma[J]. Journal of International Oncology, 2013, 40(12): 927-929.

参考文献

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