上皮-间质转化与胃癌

doi:10.3760/cma.j.issn.1673-422X.2013.12.014

摘要/Abstract

摘要： 上皮间质转化(EMT)是上皮细胞向间质细胞转化的现象。近年来发现EMT可以通过多种机制影响胃癌的发生发展，促进肿瘤细胞迁移和侵袭。EMT的发生涉及多个信号通路，与微小RNA、幽门螺杆菌、转录因子等有关，其有望成为治疗侵袭性胃癌的新靶点。

关键词: 胃肿瘤, 信号传导, 肿瘤转移, 上皮-间质转化

Abstract: Epithelialmesenchymal transition (EMT) is that cells undergo a switch from epithelial phenotype to mesenchymal phenotype. Recent researches show that EMT can affect the occurrence and development of gastric cancer through a variety of mechanisms and promote the migration and invasion of tumor cells. The process of EMT involves a number of signal transduction pathways, and is related to microRNAs, Helicobacter pylori, transcription factors and so on. EMT is expected to be a novel therapeutic target of gastric cancer.

Key words: Stomach neoplasms, Signal transduction, Neoplasm metastasis, Epithelial-mesenchymal transition

刘利敏, 李继坤. 上皮-间质转化与胃癌[J]. 国际肿瘤学杂志, 2013, 40(12): 924-926.

LIU Li-Min, LI Ji-Kun. Epithelial-mesenchymal transition and gastric cancer[J]. Journal of International Oncology, 2013, 40(12): 924-926.

参考文献

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