国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 683-686.

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趋化因子CXCL12及其受体CXCR4与乳腺癌

徐双斐,庄志刚   

  1. 200040 上海市第一妇婴保健院乳腺科
  • 出版日期:2012-09-22 发布日期:2012-09-24

CXCL12/CXCR4 and breast cancer

 XU  Shuang-Fei, ZHUANG  Zhi-Gang   

  1. Department of Breast Surgery, Shanghai First Maternal and Infant HealthCare Hospital, Shanghai 200040, China
  • Online:2012-09-22 Published:2012-09-24

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被引次数

1

摘要： 趋化因子CXCL12及其受体CXCR4在乳腺癌发生发展的多个过程中受到多种因素调控并表达，并且多项研究证实CXCL12及CXCR4不但有助于判断乳腺癌患者的预后，而且针对CXCR4的治疗更为乳腺癌患者提供了新的联合治疗方案，给患者更为理想的治疗。

关键词: 趋化因子CXCL12, 趋化因子受体CXCR4, 乳腺肿瘤

Abstract: CXCL12 and its receptor CXCR4 can express in breast cancer, and are regulated by several factors in the genesis and development of breast cancer. Lots of researches have proved that CXCL12 and CXCR4 can be used as new independent prognostic makers of breast cancer. Treatment targeted for CXCR4 can be seen as a new kind of combination therapy, which may provides patients a more ideal treatment.

Key words: Chemokine CXCL12, CXCR4 Receptor, Breast neoplasms