国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (7): 529-532.

• 综述 • 上一篇    下一篇

胃癌中微小RNA与DNA甲基化调控的关系

顾永娟,赵求,郭人花   

  1. 南京医科大学第一附属医院肿瘤内科
  • 出版日期:2012-08-06 发布日期:2012-08-06
  • 通讯作者: 郭人花，E-mail: rhguo@njmu.edu.cn E-mail:rhguo@njmu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目（81172217）

Regulatory relationships between microRNAs and DNA methylation in gastric cancer

GU  Yong-Juan, ZHAO  Qiu, GUO  Ren-Hua   

  1. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2012-08-06 Published:2012-08-06
  • Contact: GUO Ren-hua, E-mail: rhguo@njmu.edu.cn E-mail:rhguo@njmu.edu.cn

PDF

1435

摘要： 微小RNA（miRNA）是一类长度约22个核苷酸的非编码单链小分子RNA，在各种生理病理过程中发挥了重要作用，其表达失调和肿瘤的发生发展有密切联系。DNA甲基化在人类基因组中属于表观遗传学调控的范畴，无论DNA的超甲基化或低甲基化都与胃癌等多种肿瘤的发生发展有关。

关键词: 胃肿瘤, 微RNAs, DNA甲基化

Abstract: MicroRNAs (miRNAs) are a class of small (22 nucleotides) noncoding RNAs which play important roles in diverse biological and pathological processes. The dysregulation of miRNA expression is closely related to the development and progression of malignant tumors in humans. DNA methylation is a kind of epigenetic modification in human genome. Both hypermethylation and hypomethylation of DNA are closely related to different kinds of tumors, including gastric cancer.

Key words: Stomach neoplasms, MicroRNAs, DNA methylation